{"id":12603,"date":"2016-01-26T10:00:03","date_gmt":"2016-01-26T02:00:03","guid":{"rendered":"https:\/\/www.pamper.my\/news\/?p=12603"},"modified":"2016-01-27T19:17:43","modified_gmt":"2016-01-27T11:17:43","slug":"sweeter-treatment-for-breast-stomach-cancers","status":"publish","type":"post","link":"https:\/\/www.pamper.my\/news\/health\/sweeter-treatment-for-breast-stomach-cancers\/","title":{"rendered":"Sweeter Treatment for Breast & Stomach Cancers"},"content":{"rendered":"

Tweaking sugar molecules on anti-cancer antibodies improves cell-killing with fewer side effects<\/strong><\/p><\/blockquote>\n

Antibodies engineered to carry anti-cancer drugs are increasingly being used to treat a variety of diseases, including breast cancer, but next-generation treatments could be used at lower doses and have reduced side effects.<\/p>\n

Using biochemical techniques, researchers at the University of Oxford have shown that destruction of cancer cells can be enhanced by optimising trastuzumab antibodies (trade name Herceptin), used to treat HER2+ breast and stomach cancers, while reducing dose and side effects.<\/strong><\/p>\n

\"Dr.<\/a>
Dr. Weston Struwe, who is funded by Oxfordshire charity Against Breast Cancer, is one of the co-authors of the study that was published in the international journal Angewandte Chemie this month.<\/figcaption><\/figure>\n

Dr. Weston Struwe, one of the co-authors of the study,\u00a0and his colleagues used the sugars normally present on trastuzumab antibodies as a scaffold for adding anti-cancer drugs. In doing so they could modulate the amount of drug added and select for those that exhibited enhanced killing of breast cancer cells in the laboratory as well as anti-inflammatory properties, to produce a more potent treatment with reduced side effects.<\/p>\n

By producing an antibody mixture that was more than 90% pure, they propose that this new, optimized antibody drug conjugate (ADC) would work just as well at lower doses, or better, than the current antibody treatment available clinically, meaning fewer side effects would be experienced by breast cancer patients.<\/p>\n

\u201cWe are learning how to manipulate the function and biological impact of antibodies, such as Herceptin, by altering the sugar molecules that decorate them to optimize activity\u201d says Dr. Struwe. \u201cWe are now exploring how the sugars could be used to attach cell-killing components to optimized antibodies and further improve their cancer-destroying capability.\u201d<\/p>\n

Common side effects of trastuzumab treatment include fever, nausea, fatigue, diarrhoea, and sleep issues but it can also cause more serious heart, lung or liver problems. However, trastuzumab remains one of the best treatments for most types of HER2+ cancer.<\/p>\n

Source: PR Newswire
\n<\/em><\/p>\n

Read also:<\/strong>
\nNew Non-Surgical Treatment Freezes Breast Cancer in Its Tracks<\/a>;
\nMuscadine Grape Shows Promise in Fighting Cancers<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Tweaking sugar molecules on anti-cancer antibodies improves cell-killing with fewer side effects Antibodies engineered to carry anti-cancer drugs are increasingly being used to treat a variety of diseases, including breast cancer, but next-generation treatments could be used at lower doses and have reduced side effects. Using biochemical techniques, researchers at the University of Oxford have […]<\/p>\n","protected":false},"author":10,"featured_media":12605,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[18,342],"tags":[780],"yoast_head":"\nSweeter Treatment for Breast & Stomach Cancers | Pamper.My<\/title>\n<meta name=\"description\" content=\"Using biochemical techniques, researchers at the University of Oxford have shown that destruction of cancer cells can be enhanced by optimising trastuzumab antibodies (trade name Herceptin), used to treat HER2+ breast and stomach cancers, while reducing dose and side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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Therefore, knowing the risks and causes is very crucial\u2026","rel":"","context":"In "Health"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.pamper.my\/news\/wp-content\/uploads\/2017\/10\/pamper.my_breast-cancer-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":108398,"url":"https:\/\/www.pamper.my\/news\/lifestyle\/love-society\/signature-market-launches-be-a-uniquecorn-gift-box-in-support-of-breast-cancer-awareness-month\/","url_meta":{"origin":12603,"position":4},"title":"Signature Market\u00a0Launches \u2018Be A Uniquecorn\u2019 Gift Box In Support Of Breast Cancer Awareness","date":"Oct 6, 2021","format":false,"excerpt":"In conjunction with Pink October Month, Signature Market, Malaysia's FMCG Direct-to-Consumer brand, in collaboration with 12 lifestyle brands to introduce a special edition \u2018Be A Uniquecorn\u2019 gift box, where part of the proceeds from the sale will be channeled to the Breast Cancer Welfare Association Malaysia (BCWA). This initiative is\u2026","rel":"","context":"In "Love & Society"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/media.pamper.my\/2021\/10\/Signature-Market_Photo-4.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":123252,"url":"https:\/\/www.pamper.my\/news\/health\/breast-cancer-awareness-month-2023-early-detection-can-save-lives\/","url_meta":{"origin":12603,"position":5},"title":"Breast Cancer Awareness Month 2023: Early Detection Can Save Lives","date":"Oct 13, 2023","format":false,"excerpt":"Every year, October is painted in a soft shade of pink as the world comes together to commemorate Breast Cancer Awareness Month. In 2023, the spirit of solidarity and awareness shines brighter than ever. This October, the breast cancer awareness campaigns in Malaysia are fueled by an overarching goal -\u2026","rel":"","context":"In "Health"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/media.pamper.my\/2023\/10\/Breast-Cancer-Awareness-Month.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/posts\/12603"}],"collection":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/comments?post=12603"}],"version-history":[{"count":0,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/posts\/12603\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/media\/12605"}],"wp:attachment":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/media?parent=12603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/categories?post=12603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/tags?post=12603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}