{"id":12603,"date":"2016-01-26T10:00:03","date_gmt":"2016-01-26T02:00:03","guid":{"rendered":"https:\/\/www.pamper.my\/news\/?p=12603"},"modified":"2016-01-27T19:17:43","modified_gmt":"2016-01-27T11:17:43","slug":"sweeter-treatment-for-breast-stomach-cancers","status":"publish","type":"post","link":"https:\/\/www.pamper.my\/news\/health\/sweeter-treatment-for-breast-stomach-cancers\/","title":{"rendered":"Sweeter Treatment for Breast & Stomach Cancers"},"content":{"rendered":"

Tweaking sugar molecules on anti-cancer antibodies improves cell-killing with fewer side effects<\/strong><\/p><\/blockquote>\n

Antibodies engineered to carry anti-cancer drugs are increasingly being used to treat a variety of diseases, including breast cancer, but next-generation treatments could be used at lower doses and have reduced side effects.<\/p>\n

Using biochemical techniques, researchers at the University of Oxford have shown that destruction of cancer cells can be enhanced by optimising trastuzumab antibodies (trade name Herceptin), used to treat HER2+ breast and stomach cancers, while reducing dose and side effects.<\/strong><\/p>\n

\"Dr.<\/a>
Dr. Weston Struwe, who is funded by Oxfordshire charity Against Breast Cancer, is one of the co-authors of the study that was published in the international journal Angewandte Chemie this month.<\/figcaption><\/figure>\n

Dr. Weston Struwe, one of the co-authors of the study,\u00a0and his colleagues used the sugars normally present on trastuzumab antibodies as a scaffold for adding anti-cancer drugs. In doing so they could modulate the amount of drug added and select for those that exhibited enhanced killing of breast cancer cells in the laboratory as well as anti-inflammatory properties, to produce a more potent treatment with reduced side effects.<\/p>\n

By producing an antibody mixture that was more than 90% pure, they propose that this new, optimized antibody drug conjugate (ADC) would work just as well at lower doses, or better, than the current antibody treatment available clinically, meaning fewer side effects would be experienced by breast cancer patients.<\/p>\n

\u201cWe are learning how to manipulate the function and biological impact of antibodies, such as Herceptin, by altering the sugar molecules that decorate them to optimize activity\u201d says Dr. Struwe. \u201cWe are now exploring how the sugars could be used to attach cell-killing components to optimized antibodies and further improve their cancer-destroying capability.\u201d<\/p>\n

Common side effects of trastuzumab treatment include fever, nausea, fatigue, diarrhoea, and sleep issues but it can also cause more serious heart, lung or liver problems. However, trastuzumab remains one of the best treatments for most types of HER2+ cancer.<\/p>\n

Source: PR Newswire
\n<\/em><\/p>\n

Read also:<\/strong>
\nNew Non-Surgical Treatment Freezes Breast Cancer in Its Tracks<\/a>;
\nMuscadine Grape Shows Promise in Fighting Cancers<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Tweaking sugar molecules on anti-cancer antibodies improves cell-killing with fewer side effects Antibodies engineered to carry anti-cancer drugs are increasingly being used to treat a variety of diseases, including breast cancer, but next-generation treatments could be used at lower doses and have reduced side effects. Using biochemical techniques, researchers at the University of Oxford have […]<\/p>\n","protected":false},"author":10,"featured_media":12605,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","footnotes":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false,"jetpack_publicize_feature_enabled":true},"categories":[18,342],"tags":[780],"yoast_head":"\nSweeter Treatment for Breast & Stomach Cancers | Pamper.My<\/title>\n<meta name=\"description\" content=\"Using biochemical techniques, researchers at the University of Oxford have shown that destruction of cancer cells can be enhanced by optimising trastuzumab antibodies (trade name Herceptin), used to treat HER2+ breast and stomach cancers, while reducing dose and side effects.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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Therefore, knowing the risks and causes is very crucial\u2026","rel":"","context":"In "Health"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.pamper.my\/news\/wp-content\/uploads\/2017\/10\/pamper.my_breast-cancer-1.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":84070,"url":"https:\/\/www.pamper.my\/news\/health\/managing-emotional-burden-breast-cancer-treatment\/","url_meta":{"origin":12603,"position":4},"title":"Managing The Emotional Burden of Breast Cancer Treatment","date":"Oct 22, 2018","format":false,"excerpt":"There are several treatment options for treating breast cancer including surgery, chemotherapy, hormone therapy and radiotherapy. These treatments often time will cause inevitable side effects on the patients. Knowing what to expect and how to manage it can be an important tool to help the patients and their\u00a0caretakers equip themselves.\u2026","rel":"","context":"In "Health"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.pamper.my\/news\/wp-content\/uploads\/2018\/10\/shutterstock_1061797658.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":83494,"url":"https:\/\/www.pamper.my\/news\/health\/7-basic-symptoms-breast-cancer\/","url_meta":{"origin":12603,"position":5},"title":"7 Basic Symptoms of Breast Cancer","date":"Oct 15, 2018","format":false,"excerpt":"Cancer is one of the leading causes of death in the world. Compared to other cancers, breast cancer is the most common cancer in women. If breast cancer is found early, the ability to cure is up to 90%. Therefore, early detection of breast cancer symptoms is very important and\u2026","rel":"","context":"In "Health"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.pamper.my\/news\/wp-content\/uploads\/2017\/10\/pamper.my_breast-cancer.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/posts\/12603"}],"collection":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/comments?post=12603"}],"version-history":[{"count":0,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/posts\/12603\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/media\/12605"}],"wp:attachment":[{"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/media?parent=12603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/categories?post=12603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pamper.my\/news\/wp-json\/wp\/v2\/tags?post=12603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}